Cleaning an everyday office type printer usually just entails a good solid wipe down. The real trick is to not damage the printer by using cleaning items that are meant for other cleaning activities. Cleaning chemicals to avoid include alcohol or more harsh cleaning agents.
These chemicals can damage electrical areas and do more harm than good. Try and stay with light cleaning supplies like baby wipes or a damp non shedding towel. In either case, do not let water get into contact with the inside of the printer whether it is an Epson printer, canon printer or any other.
Cleaning the printer
The very first thing to do is unplug the printer. Make sure that all lights are out and that the plug is away from the unit. Open the front of the printer, with a damp non-shedding cloth give a light wipe down looking for dust build up or paper shards. If the paper has been appearing with black marks on the back, look inside the printer and wipe excess ink away. Make sure to wipe this area again so that there is no remaining moisture.
Remove each cartridge and gently wipe excess ink away. Be sure not to leave any fibrous material around exit ports. The paper receiver basket may need to be removed and check underneath for dust and paper shards around the legs. If the printer has not been used for some time a head cleaning will be needed. For a complete printer cleaning in this instance go to the control panel and printers. Here the unit will be able to run diagnostic programs and get the printer heads up.
Larger specialized printers
With larger printers designed for more specialized uses, including large format blue prints or advertising mock-ups printer cleaning requires a differing approach. An approved vacuum system is the most important tool to have on-site. This vacuum should be static free, so as not to damage interior components through static shock, and have a separate motor unit to be kept away from the printer unit.
Cleaning the printer is particularly needed in the winter and spring. In the winter the air is dry and dust is attracted. Be careful so as not to set off a static charge. In spring pollen can get anywhere no matter how you try. A printer cleaning makes all involved happier and healthier with less dust and pollen involved.